Technology
LexiNeo
LexiNeo is our next-generation system for neoantigen prediction, comprising LexiNeoTCR and LexiNeoBCR. Where DeepNeo determines whether a neoantigen can be presented and recognized, LexiNeo asks a complementary question: how well does that antigen fit the immune repertoire it will actually meet? By mapping each candidate onto the human immune landscape built from millions of T cell and B cell receptor sequences, LexiNeo adds repertoire-level context to antigen-intrinsic prediction.
- LexiNeo is designed to work alongside DeepNeo — DeepNeo’s presentation and reactivity predictions are refined by LexiNeo’s repertoire compatibility scores.
- The LexiNeo system consists of the LexiNeoTCR module, which assesses compatibility with the T cell repertoire, and the LexiNeoBCR module, which assesses compatibility with the B cell repertoire.
- Validated against thousands of neoantigens evaluated in clinical trials, the DeepNeo–LexiNeo combination identifies immunogenic targets that previous algorithms miss, substantially raising the predicted response rate for both mRNA and peptide vaccines.
